Venoms are complex mixtures of biologically active molecules that impact multiple physiological systems.Manufacture of antivenoms (AVs) therefore requires potency testing using in vivo models to ensure AV efficacy.As part of ongoing research to replace small animals as the standard model for AV potency testing, we developed an alternate in vivo met
Cardiac amyloid cardiomyopathy (CM) is a rapidly progressive disease that is frequently underrecognized and frequently diagnosed late in a significant number of individuals suffering from heart failure.Cardiac amyloid infiltration resulting in myocardial hypertrophy and restrictive CM is primarily caused by the misfolding of precursor proteins such
The work presents a simulation model of a “driver–automation–autonomous vehicles–road” system which is the basis for synthesis of automatic gear shift control system.The mathematical description makes use of physical quantities which characterise driving torque transformation from the combustion engine to the car driven wheels.The basic c
Dynamic controllability guarantees that a process control can steer the execution of a business process without violating any temporal constraints although some tasks have uncontrollable durations.However, it has been shown that dynamic controllability may lead to process executions with the undesirable property that tasks have to be started or end
This article examines the use of precedent in the judgments of international criminal courts and tribunals.It finds that although such courts and tribunals have resorted to external judicial decisions as subsidiary means for the determination Oral Care of rules of law, in some cases, their use of external judicial decisions has been equivocal.Moreo